Health

SIMNOVA - Centro interdipartimentale di Didattica Innovativa e di Simulazione in Medicina e Professioni Sanitarie

Il Centro Interdipartimentale di Didattica Innovativa e di Simulazione in Medicina e Professioni Sanitarie (SIMNOVA) nasce formalmente nel giugno 2014 presso l’Università del Piemonte Orientale. Il SIMNOVA è istituito allo scopo di svolgere attività di alta formazione, ricerca e servizi in ambito sanitario, con particolare attenzione all’uso della simulazione come strumento per innovare i programmi di formazione, migliorare la qualità della cura, ridurre il rischio clinico ed aumentare la sicurezza per i pazienti.

- Smart and functional nanobiomaterials for sense, response and remote control of biological threats to enhance on cartilage tissue regeneration

The project sets out to study new techniques for the the regeneration of cartilage tissue in the knee, in the event of minor or major damage.

These technologies include bioinks with stem cells to be used for customised 3D printing on the basis of MR images.

The technologies developed include antibacterial and anti-inflammation drugs. The project is designed to insert biosensors within the regenerated cartilage tissue in order to control its functioning from outside thanks to the ‘Internet of things’ approach.

- Selective mGlu3 metabotropic glutamate receptor ligands as new potential therapeutic agents in experimental models of parkinsonism.

Parkinson’s Disease (PD) is a chronic and progressive neurodegenerative disease with the main symptoms being loss of control over voluntary movements, as well as shaking and stiffness. The average age for emergence of the disease is around 60 years old, with a prevalence of 1-2% in the general population and 3-5% in people aged over 85.

- Mechanisms of adipose tissue dysfunction in obesity: a target of future weight loss strategies for the prevention of diabetes and cardiovascular diseases

Energy balance is a fundamental biological process, and revealing the essential mechanisms involved is an ongoing challenge in physiology and research into obesity.
 

The quantity and quality of adipose tissue (AT) are critical issues and influence metabolic and cardiovascular phenotypes in obese patients. The physiopathological factors which trigger obesity complications include altered production patterns of adipokines, lipids and miRNA which accompany the remodelling of dysfunctional AT and adiposopathy (sick fat).

- Novel IDO1 inhibitors at the forefront of cancer immunotherapy: from compound screening to preclinical validation in pancreatic ductal adenocarcinoma and glioblastoma multiforme

The project is part of a larger research area in the field of oncology, particularly in cancer immunotherapy. The project focuses on the discovery and preclinical development of ID01 inhibitors, an enzyme involved in immune escape, i.e. the ability of the tumour to evade the immune system.

- From pathobioLogy to synoviA on chip: driving rheuMatoId arthritis to the precisioN medicine GOal

Rheumatoid arthritis (RA) is an autoimmune disorder, characterised by inflammation of the synovial (joint-lining) membrane, which affects 1% of the population. If not treated, it can lead to joint deformity and permanent disability. There is not yet a cure for RA but prompt treatment with anti-rheumatic drugs (DMARD) can slow down its development, protecting joints from permanent damage.

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