Multiomics and metabolomics approach designed to decipher functional heterogeneity of myeloid cells in cancer.

Partners involved:

Università di Verona
Università di Perugia
Università Hunimed, Milan
Università di Napoli Federico II

Alzheimer’s Disease (AD) is an irreversible, progressive neurodegenerative disease. It is the most common cause of dementia in older people in developed countries: it is currently estimated to strike around 5% of people over the age of 65 and around 20% of those over 85.

The only pharmacological treatments currently available for sufferers of AD work to temporarily relieve some symptoms without impacting on its progression. They are the result of pathogenetic hypotheses (for example, the so-called cholinergic hypothesis) formulated some decades ago.

Parkinson’s Disease (PD) is a chronic and progressive neurodegenerative disease with the main symptoms being loss of control over voluntary movements, as well as shaking and stiffness. The average age for emergence of the disease is around 60 years old, with a prevalence of 1-2% in the general population and 3-5% in people aged over 85.

The project is part of a larger research area in the field of oncology, particularly in cancer immunotherapy. The project focuses on the discovery and preclinical development of ID01 inhibitors, an enzyme involved in immune escape, i.e. the ability of the tumour to evade the immune system.

The emergence and rapid global spread of SARS-CoV-2 has led to unprecedented efforts by the scientific community to understand physiopathological mechanisms of the 2019 Coronavirus – (CoViD-19).
 

The severity and mortality rate of CoViD-19 has been associated with various risk factors (e.g. hypertension, diabetes, coronary disease) but the effects of autoimmune/inflammatory diseases and related immunosuppressive treatments on CoViD-19 are still little-known.

The 4DInSiDe project sets out to improve some features of UFSD sensors, a new concept in sensor design to measure both the space and time resolution of a charged particle, with greater precision.

Specifically, the project is aimed at applications where 100% of active sensitive area is necessary (sensors with pixels of just a few hundred microns or fewer) and/or the reduction of the total thickness of the sensor of optic entrance window (allowing the use of these sensors for detection of low-energy x-ray photons).

Chemotherapy-induced periperal neuropathy (CIPN) is a dose-restricting collateral effect of various anti-cancer drugs.

Due to the fact that no cure is currently available, the only option to prevent serious and lasting damage in affected individuals is to reduce or suspend chemotherapy treatment.

This change to therapy may have an important effect in the long-term, as alternative treatments may not prove so effective. One of the reasons for the lack of a cure is the fact that the features of CIPN are still relatively unknown.

The PRIME project aims to study, develop and demonstrate advanced processes of sustainable chemistry in biorefineries that can transform sustainable raw materials and waste products in the Piedmont region into bio-products and biomaterials with functional properties equivalent to, or better than, existing alternatives on the market (with a view to circular bioeconomy and optimised use of resources).