DIMET
Department of Translational Medicine
- From pathobioLogy to synoviA on chip: driving rheuMatoId arthritis to the precisioN medicine GOal
Rheumatoid arthritis (RA) is an autoimmune disorder, characterised by inflammation of the synovial (joint-lining) membrane, which affects 1% of the population. If not treated, it can lead to joint deformity and permanent disability. There is not yet a cure for RA but prompt treatment with anti-rheumatic drugs (DMARD) can slow down its development, protecting joints from permanent damage.
- Networks of Community-based support for the elderly
The REACTION project promotes the concept of a domestic support network for senior citizens, via a “community-based support” system.
The specific goals of the project are:
- Training for Emergency Medical Teams and European Medical Corps 3.0
TEAMS 3.0 is the third in a series of projects funded by the European Commission via the Directorate-General for European Civil Protection and Humanitarian Aid Operations (DG-ECHO).
- Twinning to excel materials engineering for medical devices
The project is aimed at developing research competence in the field of medical devices and regenerative technologies.
It involves exchange programmes between doctors, researchers and PhD students.
Organisations involved
- Faculty Of Technology And Metallurgy University Of Belgrade
- AO Foundation (Davos - CH)
- Alvar Aalto Foundation (Helsinki)
- New generation cell therapy to cure type 1 Diabetes
The VANGUARD project aims to generate a bioartificial vascularized and immunoprotected pancreas that can be transplanted into non-immunosuppressed patients, combining advanced elements of tissue engineering such as 3D organoids, hydrogel design, the assembly of bioartificial organs and gene editing via CRISPR-Cas9.
This approach will produce cell therapy in the form of an advanced therapy medicinal product (ATMP), which can significantly improve the treatment of type 1 diabetes.
The project involves a consortium with 9 partners from 5 European countries.
- An integrated APProach focusEd on defining the moleculAr and biological mechanisms reguLatING viral reactivation and persistence
Persistent or latent viral infections constitute a significant problem, particularly in individuals with reduced immune systems which can easily submit to reactivation of the virus with harmful consequences for the host.
The mechanisms that result in reactivation of these viruses are still little-known, making them a sizeable challenge for scientific researchers.
The goal of this project (funded by PRIN 2017) is to increase our knowledge of virus-host interaction, in order to identify:
- Intrinsic and extrinsic innate immune surveillance against high-risk human papillomavirus infection: molecular mechanisms and novel intervention strategies
In Italy, 8.5% of cancer cases are associated with viral infections; among these, the strongest link has been found with human Papillomavirus (HPV), which contributes to 5% of tumours worldwide.
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